The study was established on a mouse model of Vascular Dementia to overcome the shortcomings of rat models of Vascular Dementia, which include high production costs, difficult surgery, surgical trauma and high mortality. In this study, repeated ischemia-reperfusion of the total bilateral carotid artery in mice, combined with a reduction of blood pressure, was used to establish an animal model of Vascular Dementia.
According to the study, a total of 40 Kunming mice were randomly divided into a sham group and a model group. Behavioral tests were performed for each group, and the morphology of the hippocampus was examined. All over the examinations were confirmed that the following surgery, learning and memory dysfunction was significantly increased in the model group.
The results of the morphological observations showed that the number of hippocampal CA1 neurons was significantly decreased in the model group compared with that in the sham surgery group.
This study was concluded that a mouse model of Vascular Dementia was successfully established, which was simple, effective and reliable, and may be used in the future to investigate Vascular Dementia.
Related Vascular Dementia Conference | Vascular Dementia Congress | Vascular Dementia Events | Vascular Dementia Meetings | Dementia Conference | Dementia Congress | Alzheimer’s Conference | Neurology Conferences | Neuroscience Conferences
13th International Conference on Alzheimer’s Disease & Dementia, November 14-15, 2019 Paris, France; 16th International conference on Dementia and Alzheimer Disease February 10-11, 2020 Sydney, Australia; 30th International Conference on Neurology and Cognitive Neuroscience February 24-25, 2020 London, UK; European Meeting on Dementia and Alzheimer Rehabilitation April 13-14, 2020 Lisbon, Portugal; 12th International Conference on Vascular Dementia June 22-23, 2020 Prague, Czech Republic;
Related Associations: Alzheimer’s Association; Dementia Society of America; National Stroke; Alzheimer’s Society; Stroke Association; Alzheimer’s disease; Alzheimer’s Research; Alzheimer Europe; Age UK; The Alzheimer’s Society of Ireland; Alzheimer Society; UCL Institute of Neurology; Alzheimer’s Society of Ontario
All accepted abstracts will be published in respective Allied Academies Journals.
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