The study was established on a mouse model of Vascular Dementia to overcome the shortcomings of rat models of Vascular Dementia, which include high production costs, difficult surgery, surgical trauma and high mortality. In this study, repeated ischemia-reperfusion of the total bilateral carotid artery in mice, combined with a reduction of blood pressure, was used to establish an animal model of Vascular Dementia.
According to the study, a total of 40 Kunming mice were randomly divided into a sham group and a model group. Behavioural tests were performed for each group, and the morphology of the hippocampus was examined. All over the examinations were confirmed that the following surgery, learning and memory dysfunction was significantly increased in the model group.
The results of the morphological observations showed that the number of hippocampal CA1 neurons was significantly decreased in the model group compared with that in the sham surgery group.
This study was concluded that a mouse model of Vascular Dementia was successfully established, which was simple, effective and reliable, and may be used in the future to investigate Vascular Dementia.
Related Vascular Dementia Conference | Vascular Dementia Congress | Vascular Dementia Events | Vascular Dementia Meetings | Dementia Conference | Dementia Congress | Alzheimer’s Conference | Neurology Conferences | Neuroscience Conferences
6th International Conference on Vascular Dementia Feb 27- Mar 01, 2017 Amsterdam, Netherlands; 11th International Conference on Vascular Dementia July 23-25, 2018 Moscow, Russia; 12th International Conference on Alzheimer’s Disease and Dementia October 29-31, 2018 Valencia, Spain; 9th International Conference and Exhibition on Dementia April 22-23, 2019 Rome, Italy; 12th World Congress on Dementia and Alzheimer Rehabilitation November 27-29, 2018 Athens, Greece; 14th World Summit on Alzheimer’s disease, Dementia Care Research and Awareness Aug 31-Sep 01, Boston Massachusetts, USA; 10th World Congress on Dementia and Alzheimer’s disease Aug 16-18, 2018 Copenhagen, Denmark; 6th International Conference on Neurodegenerative Disorders and Stroke, 5-6 July 2018, Vienna, Austria; 11th FENS Forum of Neuroscience, 7-11 July 2018, Berlin, Germany; Brain and Ocular Nutrition (BON) Conference, 11-13 July 2018, Cambridge University, UK
Related Associations: Alzheimer’s Association; Dementia Society of America; National Stroke Association; Alzheimer’s Society; Stroke Association; Alzheimer’s disease International; Alzheimer’s Research UK; Alzheimer Europe; Age UK; The Alzheimer’s Society of Ireland; Alzheimer Society of Canada; UCL Institute of Neurology; Alzheimer’s Society of Ontario
All accepted abstracts will be published in respective Allied Academies Journals.
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